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Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.

Identifieur interne : 001437 ( Main/Exploration ); précédent : 001436; suivant : 001438

Enhancing therapeutic efficacy by targeting non-oncogene addicted cells with combinations of signal transduction inhibitors and chemotherapy.

Auteurs : Stephen L. Abrams [États-Unis] ; Linda S. Steelman ; John G. Shelton ; William Chappell ; Jörg B Secke ; Franca Stivala ; Marco Donia ; Ferdinando Nicoletti ; Massimo Libra ; Alberto M. Martelli ; James A. Mccubrey

Source :

RBID : pubmed:20436269

Descripteurs français

English descriptors

Abstract

The effects of inhibition of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways and chemotherapeutic drugs on cell cycle progression and drug sensitivity were examined in cytokine-dependent FL5.12 hematopoietic cells. We examined their effects, as these cells resemble normal hematopoietic precursor cells as they do not exhibit "oncogene-addicted" growth, while they do display "cytokine-addicted" proliferation as cytokine removal resulted in apoptosis in greater than 80% of the cells within 48 hrs. When cytokine-dependent FL5.12 cells were cultured in the presence of IL-3, which stimulated multiple proliferation and anti-apoptotic cascades, MEK, PI3K and mTOR inhibitors transiently suppressed but did not totally inhibit cell cycle progression or induce apoptosis while chemotherapeutic drugs such as doxorubicin and paclitaxel were more effective in inducing cell cycle arrest and apoptosis. Doxorubicin induced a G(1) block, while paclitaxel triggered a G(2)/M block. Doxorubicin was more effective in inducing cell death than paclitaxel. Furthermore the effects of doxorubicin could be enhanced by addition of MEK, PI3K or mTOR inhibitors. Cytokine-dependent cells which proliferate in vitro and are not "oncogene-addicted" may represent a pre-malignant stage, more refractory to treatment with targeted therapy. However, these cells are sensitive to chemotherapeutic drugs. It is important to develop methods to inhibit the growth of such cytokine-dependent cells as they may resemble the leukemia stem cell and other cancer initiating cells. These results demonstrate the enhanced effectiveness of targeting early hematopoietic progenitor cells with combinations of chemotherapeutic drugs and signal transduction inhibitors.

DOI: 10.4161/cc.9.9.11544
PubMed: 20436269
PubMed Central: PMC3781183


Affiliations:


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Le document en format XML

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<term>Antineoplastic Agents (therapeutic use)</term>
<term>Apoptosis (MeSH)</term>
<term>Butadienes (therapeutic use)</term>
<term>Cell Line, Tumor (MeSH)</term>
<term>Chromones (therapeutic use)</term>
<term>Doxorubicin (therapeutic use)</term>
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<term>Interleukin-3 (therapeutic use)</term>
<term>Intracellular Signaling Peptides and Proteins (antagonists & inhibitors)</term>
<term>Intracellular Signaling Peptides and Proteins (metabolism)</term>
<term>Leukemia, Prolymphocytic (drug therapy)</term>
<term>Mice (MeSH)</term>
<term>Mitogen-Activated Protein Kinase Kinases (antagonists & inhibitors)</term>
<term>Mitogen-Activated Protein Kinase Kinases (metabolism)</term>
<term>Morpholines (therapeutic use)</term>
<term>Nitriles (therapeutic use)</term>
<term>Paclitaxel (therapeutic use)</term>
<term>Phosphatidylinositol 3-Kinases (metabolism)</term>
<term>Phosphoinositide-3 Kinase Inhibitors (MeSH)</term>
<term>Protein-Serine-Threonine Kinases (antagonists & inhibitors)</term>
<term>Protein-Serine-Threonine Kinases (metabolism)</term>
<term>Signal Transduction (drug effects)</term>
<term>Sirolimus (therapeutic use)</term>
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<term>Animaux (MeSH)</term>
<term>Antibiotiques antinéoplasiques (usage thérapeutique)</term>
<term>Antinéoplasiques (usage thérapeutique)</term>
<term>Apoptose (MeSH)</term>
<term>Butadiènes (usage thérapeutique)</term>
<term>Doxorubicine (usage thérapeutique)</term>
<term>Interleukine-3 (usage thérapeutique)</term>
<term>Leucémie prolymphocytaire (traitement médicamenteux)</term>
<term>Lignée cellulaire tumorale (MeSH)</term>
<term>Mitogen-Activated Protein Kinase Kinases (antagonistes et inhibiteurs)</term>
<term>Mitogen-Activated Protein Kinase Kinases (métabolisme)</term>
<term>Morpholines (usage thérapeutique)</term>
<term>Nitriles (usage thérapeutique)</term>
<term>Paclitaxel (usage thérapeutique)</term>
<term>Phase G1 (MeSH)</term>
<term>Phosphatidylinositol 3-kinases (métabolisme)</term>
<term>Protein-Serine-Threonine Kinases (antagonistes et inhibiteurs)</term>
<term>Protein-Serine-Threonine Kinases (métabolisme)</term>
<term>Protéines et peptides de signalisation intracellulaire (antagonistes et inhibiteurs)</term>
<term>Protéines et peptides de signalisation intracellulaire (métabolisme)</term>
<term>Sirolimus (usage thérapeutique)</term>
<term>Souris (MeSH)</term>
<term>Sérine-thréonine kinases TOR (MeSH)</term>
<term>Transduction du signal (effets des médicaments et des substances chimiques)</term>
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<term>Intracellular Signaling Peptides and Proteins</term>
<term>Mitogen-Activated Protein Kinase Kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
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<term>Intracellular Signaling Peptides and Proteins</term>
<term>Mitogen-Activated Protein Kinase Kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
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<term>Antineoplastic Agents</term>
<term>Butadienes</term>
<term>Chromones</term>
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<term>Morpholines</term>
<term>Nitriles</term>
<term>Paclitaxel</term>
<term>Sirolimus</term>
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<term>Mitogen-Activated Protein Kinase Kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines et peptides de signalisation intracellulaire</term>
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<term>Transduction du signal</term>
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<term>Phosphatidylinositol 3-Kinases</term>
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<term>Mitogen-Activated Protein Kinase Kinases</term>
<term>Phosphatidylinositol 3-kinases</term>
<term>Protein-Serine-Threonine Kinases</term>
<term>Protéines et peptides de signalisation intracellulaire</term>
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<term>Leucémie prolymphocytaire</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr">
<term>4H-1-Benzopyran-4-ones</term>
<term>Antibiotiques antinéoplasiques</term>
<term>Antinéoplasiques</term>
<term>Butadiènes</term>
<term>Doxorubicine</term>
<term>Interleukine-3</term>
<term>Morpholines</term>
<term>Nitriles</term>
<term>Paclitaxel</term>
<term>Sirolimus</term>
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<term>Cell Line, Tumor</term>
<term>G1 Phase</term>
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<term>TOR Serine-Threonine Kinases</term>
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<term>Apoptose</term>
<term>Lignée cellulaire tumorale</term>
<term>Phase G1</term>
<term>Souris</term>
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<div type="abstract" xml:lang="en">The effects of inhibition of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways and chemotherapeutic drugs on cell cycle progression and drug sensitivity were examined in cytokine-dependent FL5.12 hematopoietic cells. We examined their effects, as these cells resemble normal hematopoietic precursor cells as they do not exhibit "oncogene-addicted" growth, while they do display "cytokine-addicted" proliferation as cytokine removal resulted in apoptosis in greater than 80% of the cells within 48 hrs. When cytokine-dependent FL5.12 cells were cultured in the presence of IL-3, which stimulated multiple proliferation and anti-apoptotic cascades, MEK, PI3K and mTOR inhibitors transiently suppressed but did not totally inhibit cell cycle progression or induce apoptosis while chemotherapeutic drugs such as doxorubicin and paclitaxel were more effective in inducing cell cycle arrest and apoptosis. Doxorubicin induced a G(1) block, while paclitaxel triggered a G(2)/M block. Doxorubicin was more effective in inducing cell death than paclitaxel. Furthermore the effects of doxorubicin could be enhanced by addition of MEK, PI3K or mTOR inhibitors. Cytokine-dependent cells which proliferate in vitro and are not "oncogene-addicted" may represent a pre-malignant stage, more refractory to treatment with targeted therapy. However, these cells are sensitive to chemotherapeutic drugs. It is important to develop methods to inhibit the growth of such cytokine-dependent cells as they may resemble the leukemia stem cell and other cancer initiating cells. These results demonstrate the enhanced effectiveness of targeting early hematopoietic progenitor cells with combinations of chemotherapeutic drugs and signal transduction inhibitors.</div>
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<AbstractText>The effects of inhibition of the Raf/MEK/ERK and PI3K/Akt/mTOR signaling pathways and chemotherapeutic drugs on cell cycle progression and drug sensitivity were examined in cytokine-dependent FL5.12 hematopoietic cells. We examined their effects, as these cells resemble normal hematopoietic precursor cells as they do not exhibit "oncogene-addicted" growth, while they do display "cytokine-addicted" proliferation as cytokine removal resulted in apoptosis in greater than 80% of the cells within 48 hrs. When cytokine-dependent FL5.12 cells were cultured in the presence of IL-3, which stimulated multiple proliferation and anti-apoptotic cascades, MEK, PI3K and mTOR inhibitors transiently suppressed but did not totally inhibit cell cycle progression or induce apoptosis while chemotherapeutic drugs such as doxorubicin and paclitaxel were more effective in inducing cell cycle arrest and apoptosis. Doxorubicin induced a G(1) block, while paclitaxel triggered a G(2)/M block. Doxorubicin was more effective in inducing cell death than paclitaxel. Furthermore the effects of doxorubicin could be enhanced by addition of MEK, PI3K or mTOR inhibitors. Cytokine-dependent cells which proliferate in vitro and are not "oncogene-addicted" may represent a pre-malignant stage, more refractory to treatment with targeted therapy. However, these cells are sensitive to chemotherapeutic drugs. It is important to develop methods to inhibit the growth of such cytokine-dependent cells as they may resemble the leukemia stem cell and other cancer initiating cells. These results demonstrate the enhanced effectiveness of targeting early hematopoietic progenitor cells with combinations of chemotherapeutic drugs and signal transduction inhibitors.</AbstractText>
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<ReferenceList>
<Reference>
<Citation>Leukemia. 2008 Jan;22(1):147-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17928881</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Jan 15;7(2):216-21</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18256527</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Virol. 2008 Apr;82(7):3796-802</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18216097</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Biol Ther. 2007 Nov;6(11):1684-90</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18344680</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Apr;22(4):708-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18337766</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Apr;22(4):686-707</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18337767</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Feb 15;7(4):533-41</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18431843</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Apr 15;7(8):965-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18414037</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 May 15;7(10):1360-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18418062</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 May 15;7(10):1371-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18421251</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Jun;22(6):1106-16</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18385752</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Jun 1;7(11):1604-12</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18520179</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene. 2008 Jul 3;27(29):4086-95</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18332865</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 May 1;8(9):1373-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19305144</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 May 1;8(9):1352-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19305151</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 May 1;8(9):1338-43</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19342894</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 May 15;8(10):1515-25</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19377304</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Rejuvenation Res. 2008 Aug;11(4):801-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18729812</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jun 1;8(11):1711-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19411846</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jun 15;8(12):1883-7</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19448395</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jun 15;8(12):1888-95</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19471117</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jun 15;8(12):1901-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19471118</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jun 15;8(12):1896-900</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19478560</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jul 1;8(13):2005-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19550141</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Aug 15;8(16):2509-17</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19633417</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Sep 1;8(17):2810-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19657224</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Sep 15;8(18):2975-83</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19713744</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Sep 15;8(18):2951-63</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19713770</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Oct 1;8(19):3208-17</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19738435</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Oct 1;8(19):3120-4</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19755852</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Oct 15;8(20):3303-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19806030</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Adv Enzyme Regul. 2010;50(1):285-307</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19895837</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Expert Opin Emerg Drugs. 2010 Jun;15(2):203-23</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20151845</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2010 May;9(9):1781-91</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20436278</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2010 Apr 15;9(8):1629-38</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">20372086</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Jul 1;7(13):1973-82</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18604177</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Aug;7(15):2427-33</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18677110</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Jun 15;7(12):1745-62</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18594202</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Sep 1;7(17):2615-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18719390</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Sep 1;7(17):2661-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18728388</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Sep 15;7(18):2877-85</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18769155</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Oct;7(19):2949-55</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18818517</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Oct;22(10):1899-908</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18650843</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Oct;7(20):3133-6</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18927504</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Nov;22(11):2080-90</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18685611</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Nov 1;7(21):3355-61</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18948731</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Nov 1;7(21):3362-70</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18948750</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Nov 1;7(21):3344-54</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18971624</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Nov 1;7(21):3448-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18971636</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2009 Jan;23(1):25-42</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">18800146</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Dec 15;7(24):3798-804</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19066464</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2008 Dec 15;7(24):3805-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19098454</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Jan 1;8(1):158-66</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19158483</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Feb 1;8(3):403-13</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19177005</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nat Struct Mol Biol. 2009 Mar;16(3):294-303</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19219045</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Apr 1;8(7):1000-2</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19270518</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 Apr 1;8(7):1026-9</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19270529</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cancer Res. 2009 Apr 15;69(8):3520-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19351820</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2009 May 1;8(9):1314-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">19279406</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Growth Differ. 1996 Apr;7(4):487-500</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">9052990</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 1997 Oct;11(10):1711-25</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">9324293</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2006 Jun;20(6):911-28</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16642045</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2006 May 25;441(7092):475-82</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16598206</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Nature. 2006 May 25;441(7092):518-22</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16633340</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2006 Jul;20(7):1254-60</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16642049</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Blood. 2006 Oct 1;108(7):2358-65</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">16763210</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell. 2000 Feb 18;100(4):387-90</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">10693755</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2000 Oct;14(10):1777-84</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11021753</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene. 2001 Jul 19;20(32):4354-64</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">11466616</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene. 2003 Apr 24;22(16):2478-92</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12717425</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Blood. 2003 Aug 1;102(3):972-80</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">12702506</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Proc Natl Acad Sci U S A. 1985 Nov;82(21):7414-8</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">3933007</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Oncogene Res. 1989;4(2):97-109</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">2785667</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Blood. 1995 Oct 15;86(8):3139-50</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">7579409</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2007 Mar;21(3):427-38</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17215852</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2007 May;21(5):886-96</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17361225</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Biochim Biophys Acta. 2007 Aug;1773(8):1263-84</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17126425</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Exp Hematol. 2007 Oct;35(10):1538-49</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17889721</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Cell Cycle. 2007 Sep 15;6(18):2268-75</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17890906</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>J Cell Biochem. 2007 Dec 15;102(6):1389-99</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17975792</ArticleId>
</ArticleIdList>
</Reference>
<Reference>
<Citation>Leukemia. 2008 Jan;22(1):198-200</Citation>
<ArticleIdList>
<ArticleId IdType="pubmed">17625605</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations>
<list>
<country>
<li>États-Unis</li>
</country>
<region>
<li>Caroline du Nord</li>
</region>
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<name sortKey="Libra, Massimo" sort="Libra, Massimo" uniqKey="Libra M" first="Massimo" last="Libra">Massimo Libra</name>
<name sortKey="Martelli, Alberto M" sort="Martelli, Alberto M" uniqKey="Martelli A" first="Alberto M" last="Martelli">Alberto M. Martelli</name>
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